Article

Systemic Sclerosis dermal fibroblast exosomes trigger a Type 1 interferon response in keratinocytes through the TBK/JAK/STAT signalling axis

2023-12-14

Abstract excerpt

<h4>Background</h4> Activation of Type I IFN response has been shown to correlates with disease activity in systemic sclerosis. It is currently unknown whether the tissue-specific Type I IFN activation is a consequence of the response observed in blood or rather its source. Exosomes from SSc fibroblasts were recently shown to activate macrophages in vitro . Here, we aimed to determine the source of Type I IFN si...

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Literature Corpus work: a6c36817-0287-5612-b316-6d46ab27f96d
DOI: 10.1101/2023.12.14.570365

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Systemic Sclerosis dermal fibroblast exosomes trigger a Type 1 interferon response in keratinocytes through the TBK/JAK/STAT signalling axisDOI 10.1101/2023.12.14.570365Read

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