Article

Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritis

2026-07-02

Abstract excerpt

Joint involvement is a major driver of disability in systemic sclerosis (SSc), yet its pathophysiology remains poorly understood. In the absence of specific evidence, SSc synovitis is treated by analogy with rheumatoid arthritis (RA). Here, we present the first comprehensive molecular characterization of SSc synovitis, integrating histology, single-cell RNA sequencing, and spatial multi-omics of synovial biopsies...

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Literature Corpus work: d112c6f3-8e7d-5d7c-983b-19b12a25200a
DOI: 10.64898/2026.06.30.733140

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