Back to search

Article

RNA-Seq analysis identifies novel roles for the primary cilia gene <i>SPAG17</i> and the <i>SOX9</i> locus non-coding RNAs in systemic sclerosis

2021-11-21

Abstract excerpt

Systemic sclerosis ( SSc ) is characterized by immune activation, vasculopathy, and unresolving fibrosis in the skin, lungs, and other organs. We performed RNA-Seq analysis on skin biopsies and peripheral blood mononuclear cells ( PBMCs ) from SSc patients and controls to better understand SSc pathogenesis. We analyzed these data to 1) test for case-control differences, and 2) identify genes whose expression lev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a19d53a3-594a-5fcf-9fe4-7d41ec8632d9
DOI
10.1101/2021.11.20.468677
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
RNA-Seq analysis identifies novel roles for the primary cilia gene <i>SPAG17</i> and the <i>SOX9</i> locus non-coding RNAs in systemic sclerosisDOI 10.1101/2021.11.20.468677
Alterations of the Primary Cilia Gene SPAG17 and SOX9 Locus Noncoding RNAs Identified by RNA‐Sequencing Analysis in Patients With Systemic SclerosisSemantic proximity
Mapping spatially-resolved transcriptomes in systemic sclerosisSemantic proximity
Updates on genetics in systemic sclerosisSemantic proximity
Genome-wide whole blood transcriptome profiling in a large European cohort of systemic sclerosis patientsSemantic proximity
Single-Cell Transcriptome Analysis Identifies Subclusters with Inflammatory Fibroblast Responses in Localized SclerodermaSemantic proximity
Transcriptional landscape of CD4+ T cells in Systemic SclerosisSemantic proximity
Systemic sclerosis pathogenesis: contribution of recent advances in genetics.Semantic proximity
Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic SclerosisSemantic proximity
Functional genomics in primary T cells and monocytes identifies mechanisms by which genetic susceptibility loci influence systemic sclerosis riskSemantic proximity
Unfolding the pathogenesis of scleroderma through genomics and epigenomics.Semantic proximity
Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory GenesSemantic proximity
Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritisSemantic proximity
Select a neighboring publication to make it the new centre.