Back to search

Article

Long Non-Coding RNA XIST and TSIX Modulate TGF-β-Mediated Cellular Transdifferentiation and Fibrosis in Systemic Sclerosis

2026-08-14

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Systemic sclerosis (SSc) is a complex autoimmune disease characterized by immune dysregulation, microvascular injury, and progressive fibrosis, with transforming growth factor-β (TGF-β) serving as a central driver of fibrotic responses. Although the long non-coding RNAs (lncRNAs) XIST and TSIX are recognized as important epigenetic regulators, their contributi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2ab3dcac-ca00-51ae-9561-8c77ce3bd367
DOI
10.21203/rs.3.rs-10659102/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Long Non-Coding RNA XIST and TSIX Modulate TGF-β-Mediated Cellular Transdifferentiation and Fibrosis in Systemic SclerosisDOI 10.21203/rs.3.rs-10659102/v1
Pathogenic Roles of Autoantibodies and Aberrant Epigenetic Regulation of Immune and Connective Tissue Cells in the Tissue Fibrosis of Patients with Systemic SclerosisSemantic proximity
A review of recent studies on the pathogenesis of Systemic Sclerosis: focus on fibrosis pathwaysSemantic proximity
Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAsSemantic proximity
Transcriptional landscape of CD4+ T cells in Systemic SclerosisSemantic proximity
Epigenetics, the holy grail in the pathogenesis of systemic sclerosisSemantic proximity
The Role of Non‐Coding RNA in Systemic Sclerosis: From Mechanism to TranslationSemantic proximity
The Evolving Landscape of Systemic Sclerosis Pathogenesis: From Foundational Mechanisms to Organ-Specific ModifiersSemantic proximity
MicroRNAs in Systemic Sclerosis: Involvement in Disease Pathogenesis and Potential Use as Diagnostic Biomarkers and Therapeutic TargetsSemantic proximity
Unfolding the pathogenesis of scleroderma through genomics and epigenomics.Semantic proximity
Systemic sclerosis: an update.Semantic proximity
MicroRNAs: their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in sclerodermaSemantic proximity
Epigenetic Factors as Drivers of Fibrosis in Systemic SclerosisSemantic proximity
Select a neighboring publication to make it the new centre.