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Article

BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs

5 Jun 2021

Abstract excerpt

BACKGROUND: Systemic sclerosis (SSc) is a disease that features severe fibrosis of the skin and lacks effective therapy. Bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs) are potential stem cell-based tools for the treatment of SSc. METHODS: BMSCs were isolated from the bone marrow of mice and identified with surface markers according to multilineage differentiation. EVs were isolated...

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PMID: 34090522
DOI: 10.1186/s13287-021-02400-y

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