Article

The androgen receptor does not directly regulate the transcription of DNA damage response genes

2023-05-14

Abstract excerpt

The clinical success of combined androgen deprivation therapy (ADT) and radiation therapy (RT) in prostate cancer (PCa) created interest in understanding the mechanistic links between androgen receptor (AR) signaling and the DNA damage response (DDR). Convergent data have led to a model where AR both regulates, and is regulated by, the DDR. Integral to this model is that the AR regulates the transcription of DDR g...

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Literature Corpus work: a6a8c53b-d33e-53fa-9790-58185b654063
DOI: 10.1101/2023.05.13.540653

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