Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate

Abstract excerpt

Abstract The androgen receptor (AR) is central in prostate tissue identity and differentiation, and controls normal growth-suppressive, prostate-specific gene expression. It also drives prostate tumorigenesis when hijacked for oncogenic transcription. The execution of growth-suppressive AR transcriptional programs in prostate cancer (PCa) and the potential for reactivation remain unclear. Here, we use a...

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• Genomics and Chromatin Dynamics
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