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The interconnection between androgen receptor and DNA damage response pathways in prostate cancer

18 Aug 2025

Abstract excerpt

The androgen receptor (AR) plays a critical role in the development and progression of prostate cancer by regulating key cellular processes such as cell proliferation and apoptosis. Although traditional AR-targeted therapies have shown initial success, acquired resistance remains a significant clinical challenge, often driven by AR alterations and somatic gene mutations associated with homologous recombination...

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PMID: 41058763
DOI: 10.1097/cu9.0000000000000300

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