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Article

Role of the DNA damage response in prostate cancer formation, progression and treatment

13 Jun 2019

Abstract excerpt

BACKGROUND: Clinical and preclinical studies have revealed that alterations in DNA damage response (DDR) pathways may play an important role in prostate cancer (PCa) etiology and progression. These alterations can influence PCa responses to radiotherapy and anti-androgen treatment. The identification of DNA repair gene aberrations in PCa has driven the interest for further evaluation whether these genetic changes...

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PMID: 31197228
DOI: 10.1038/s41391-019-0153-2

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