Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential modulation of the androgen receptor for prostate cancer therapy depends on the DNA response element

16 Mar 2020

Abstract excerpt

Androgen receptor (AR) action is a hallmark of prostate cancer (PCa) with androgen deprivation being standard therapy. Yet, resistance arises and aberrant AR signaling promotes disease. We sought compounds that inhibited genes driving cancer but not normal growth and hypothesized that genes with consensus androgen response elements (cAREs) drive proliferation but genes with selective elements (sAREs) promote...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to PARP inhibition in cancer therapy
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32198885
DOI: 10.1093/nar/gkaa178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential modulation of the androgen receptor for prostate cancer therapy depends on the DNA response elementPMID 32198885Read ↗

Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostateSemantic proximity Read ↗

Canonical AREs are tumor suppressive regulatory elements in the prostateSemantic proximity Read ↗

The androgen receptor does not directly regulate the transcription of DNA damage response genesSemantic proximity Read ↗

The Androgen Receptor Does Not Directly Regulate the Transcription of DNA Damage Response GenesSemantic proximity Read ↗

Cellular specificity of androgen receptor, coregulators, and pioneer factors in prostate cancerSemantic proximity Read ↗

Sequencing the transcriptional network of androgen receptor in prostate cancer.Semantic proximity Read ↗

Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potentialSemantic proximity Read ↗

A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancerSemantic proximity Read ↗

Androgen receptor enhancer usage and the chromatin regulatory landscape in human prostate cancersSemantic proximity Read ↗

Capped nascent RNA sequencing reveals novel therapy-responsive enhancers in prostate cancerSemantic proximity Read ↗

Identification of a Clinically Relevant Androgen-Dependent Gene Signature in Prostate CancerSemantic proximity Read ↗

Androgen Receptor Reprogramming Demarcates Prognostic Gene Sets In Prostate CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.