Article

Enhanced 5mC-Methylation-Site Recognition in DNA Sequences using Token Classification and a Domain-specific Loss Function

2023-06-05

Abstract excerpt

DNA 5-methylcytosine modification has been widely studied in mammals and plays an important role in epigenetics. Several computational methods exist that attempt to determine the methylation state of a DNA sequence centered at a possible methylation site. Here, we introduce a novel deep-learning framework, MR-DNA, that predicts the methylation state of a single nucleotide located in a gene promoter region. The ide...

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Literature Corpus work: a68823d6-0b3e-5b39-96ac-52318b39d3d9
DOI: 10.1101/2023.06.01.543218

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