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Article

Structure of the human multidrug transporter ABCG2.

Nature - 22 Jun 2017

Taylor Nicholas M I, Manolaridis Ioannis, Jackson Scott M, Kowal Julia, Stahlberg Henning, Locher Kaspar P

Abstract excerpt

ABCG2 is a constitutively expressed ATP-binding cassette (ABC) transporter that protects many tissues against xenobiotic molecules. Its activity affects the pharmacokinetics of commonly used drugs and limits the delivery of therapeutics into tumour cells, thus contributing to multidrug resistance. Here we present the structure of human ABCG2 determined by cryo-electron microscopy, providing the first...

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Share to Adenosine Triphosphatases
Share to Antibodies
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28554189
DOI: 10.1038/nature22345

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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