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Article

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression.

Scientific reports - 10 May 2018

Zámbó Boglárka, Bartos Zsuzsa, Mózner Orsolya, Szabó Edit, Várady György, Poór Gyula, Pálinkás Márton, Andrikovics Hajnalka, Hegedűs Tamás, Homolya László, Sarkadi Balázs

Abstract excerpt

The ABCG2 membrane protein is a key xeno- and endobiotic transporter, modulating the absorption and metabolism of pharmacological agents and causing multidrug resistance in cancer. ABCG2 is also involved in uric acid elimination and its impaired function is causative in gout. Analysis of ABCG2 expression in the erythrocyte membranes of healthy volunteers and gout patients showed an enrichment of lower expression...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29749379
DOI: 10.1038/s41598-018-25695-z
PMCID: PMC5945641

Genes

ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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