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Article

The chromatin insulator CTCF regulates HPV18 transcript splicing and differentiation-dependent late gene expression

4 Nov 2021

Abstract excerpt

The ubiquitous host protein, CCCTC-binding factor (CTCF), is an essential regulator of cellular transcription and functions to maintain epigenetic boundaries, stabilise chromatin loops and regulate splicing of alternative exons. We have previously demonstrated that CTCF binds to the E2 open reading frame (ORF) of human papillomavirus (HPV) 18 and functions to repress viral oncogene expression in undifferentiated...

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PMID: 34735550
DOI: 10.1371/journal.ppat.1010032

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