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Article

High-Fat Diet-Induced Dysregulation of Immune Cells Correlates with Macrophage Phenotypes and Chronic Inflammation in Adipose Tissue.

Cells - 13 Apr 2022

Kiran Sonia, Rakib Ahmed, Kodidela Sunitha, Kumar Santosh, Singh Udai P

Abstract excerpt

Obesity is a complex disease associated with various metabolic abnormalities, cardiovascular diseases, and low-grade chronic inflammation. Inflammation associated with T helper 1 (Th1) immune cells is dominant in adipose tissue (AT) and exerts metabolically deleterious impacts. The precise mechanism of alteration in AT immune system and its effect on metabolic homeostasis remains unclear. In this study, we...

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Identifiers

PMID: 35456006
DOI: 10.3390/cells11081327
PMCID: PMC9031506

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