Article
Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA.
Diabetes - 1 Dec 2014
Reddy Marpadga A, Chen Zhuo, Park Jung Tak, Wang Mei, Lanting Linda, Zhang Qiang, Bhatt Kirti, Leung Amy, Wu Xiwei, Putta Sumanth, Sætrom Pål, Devaraj Sridevi, Natarajan Rama
Abstract excerpt
The mechanisms by which macrophages mediate the enhanced inflammation associated with diabetes complications are not completely understood. We used RNA sequencing to profile the transcriptome of bone marrow macrophages isolated from diabetic db/db mice and identified 1,648 differentially expressed genes compared with control db/+ mice. Data analyses revealed that diabetes promoted a proinflammatory, profibrotic,...
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