Article

Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity

2024-08-27

Abstract excerpt

<h4>ABSTRACT</h4> In fibrotic tissues, activated fibroblasts remodel the collagen-rich extracellular matrix (ECM). Intervening with this process represents a candidate therapeutic strategy to attenuate disease progression. Models that generate quantitative data on 3D fibroblast-mediated ECM remodeling with the reproducibility and throughput needed for drug testing are lacking. Here, we develop a model that fits t...

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Literature Corpus work: a64030c5-2f8a-5249-ac66-60fe911f4c49
DOI: 10.1101/2024.08.26.609699

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