Article

Computational Analysis of Fibroblast Subpopulation Dynamics as a Driver of Fibrotic Foci Formation

2026-08-04

Abstract excerpt

Fibroblasts maintain the extracellular matrix (ECM) to support tissue homeostasis and wound healing. In fibrotic diseases, fibroblasts are a primary driver of disease progression through excess collagen secretion and enhanced contractility. Replacing native tissue with a collagen rich fibrotic scar leads to a decline in tissue function. Recent research into idiopathic pulmonary fibrosis (IPF) has identified fibrob...

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Literature Corpus work: 53eed43f-6561-5247-a8de-da9b1c3c8dd7
DOI: 10.64898/2026.08.03.742640

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