Article
Studying Activated Fibroblast Phenotypes and Fibrosis-Linked Mechanosensing Using 3D Biomimetic Models.
Macromolecular bioscience - 1 Apr 2022
Paradiso Francesca, Quintela Marcos, Lenna Stefania, Serpelloni Stefano, James David, Caserta Sergio, Conlan Steve, Francis Lewis, Taraballi Francesca
Abstract excerpt
Fibrosis and solid tumor progression are closely related, with both involving pathways associated with chronic wound dysregulation. Fibroblasts contribute to extracellular matrix (ECM) remodeling in these processes, a crucial step in scarring, organ failure, and tumor growth, but little is known about the biophysical evolution of remodeling regulation during the development and progression of matrix-related...
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