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Article

Targeted single molecule mutation detection with massively parallel sequencing.

Nucleic acids research - 18 Feb 2016

Gregory Mark T, Bertout Jessica A, Ericson Nolan G, Taylor Sean D, Mukherjee Rithun, Robins Harlan S, Drescher Charles W, Bielas Jason H

Abstract excerpt

Next-generation sequencing (NGS) technologies have transformed genomic research and have the potential to revolutionize clinical medicine. However, the background error rates of sequencing instruments and limitations in targeted read coverage have precluded the detection of rare DNA sequence variants by NGS. Here we describe a method, termed CypherSeq, which combines double-stranded barcoding error correction and...

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Identifiers

PMID: 26384417
DOI: 10.1093/nar/gkv915
PMCID: PMC4756847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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