Article
Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing.
PloS one - 1 Jan 2015
Ahn Eun Hyun, Hirohata Kensen, Kohrn Brendan F, Fox Edward J, Chang Chia-Cheng, Loeb Lawrence A
Abstract excerpt
Long-lived adult stem cells could accumulate non-repaired DNA damage or mutations that increase the risk of tumor formation. To date, studies on mutations in stem cells have concentrated on clonal (homoplasmic) mutations and have not focused on rarely occurring stochastic mutations that may accumulate during stem cell dormancy. A major challenge in investigating these rare mutations is that conventional next...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.