Article

Quantifying the extent to which index event biases influence large genetic association studies

2016-09-12

Abstract excerpt

As genetic association studies increase in size to 100,000s of individuals, subtle biases may influence conclusions. One possible bias is “index event bias” (IEB), also called “collider bias”, caused by the stratification by, or enrichment for, disease status when testing associations between gene variants and a disease-associated trait. We first provided a statistical framework for quantifying IEB then identified...

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Literature Corpus work: a61f12e9-06b9-5d7b-b567-d9bea1e2fe54
DOI: 10.1101/074781

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