Article

Representation in genetic studies affects inference about genetic architecture

2026-01-13

Abstract excerpt

Knowledge of a trait’s “genetic architecture,” namely the joint distribution of allele frequencies of causal variants and the direction and magnitude of their effects, is essential to understanding its evolution and underlying biology. Inferences about genetic architecture are based on data collected in heterogeneous ways in cohorts recruited through heterogeneous mechanisms. As a result, cohorts differ in genotyp...

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Literature Corpus work: b3e6abf9-f8d6-5a45-9365-6d877c404e97
DOI: 10.64898/2026.01.12.699135

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