Article
Quantifying the extent to which index event biases influence large genetic association studies.
Human molecular genetics - 1 Mar 2017
Yaghootkar Hanieh, Bancks Michael P, Jones Sam E, McDaid Aaron, Beaumont Robin, Donnelly Louise, Wood Andrew R, Campbell Archie, Tyrrell Jessica, Hocking Lynne J, Tuke Marcus A, Ruth Katherine S, Pearson Ewan R, Murray Anna, Freathy Rachel M, Munroe Patricia B, Hayward Caroline, Palmer Colin, Weedon Michael N, Pankow James S, Frayling Timothy M, Kutalik Zoltán
Abstract excerpt
As genetic association studies increase in size to 100 000s of individuals, subtle biases may influence conclusions. One possible bias is 'index event bias' (IEB) that appears due to the stratification by, or enrichment for, disease status when testing associations between genetic variants and a disease-associated trait. We aimed to test the extent to which IEB influences some known trait associations in a range...
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