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Article

Correcting for volunteer bias in GWAS increases SNP effect sizes and heritability estimates.

Nature communications - 15 Apr 2025

van Alten Sjoerd, Domingue Benjamin W, Faul Jessica, Galama Titus, Marees Andries T

Abstract excerpt

Selection bias in genome-wide association studies (GWASs) due to volunteer-based sampling (volunteer bias) is poorly understood. The UK Biobank (UKB), one of the largest and most widely used cohorts, is highly selected. Using inverse probability (IP) weights we estimate inverse probability weighted GWAS (WGWAS) to correct GWAS summary statistics in the UKB for volunteer bias. Our IP weights were estimated using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40234401
DOI: 10.1038/s41467-025-58684-8
PMCID: PMC12000612

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