Article

An empirical investigation into the impact of winner’s curse on estimates from Mendelian randomization

2022-08-06

Abstract excerpt

<h4>Introduction</h4> Genetic associations for variants identified through genome-wide association studies (GWAS) tend to be overestimated in the original discovery dataset; as if the association was underestimated, the variant may not have been detected. This bias, known as winner’s curse, can affect Mendelian randomization estimates, but its severity and potential impact is unclear. <h4>Methods</h4> We performed...

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Literature Corpus work: 595472e0-8ab9-547e-b972-521aa42018ca
DOI: 10.1101/2022.08.05.22278470

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