Article

Inhibition of E2F-1 Transactivation by Direct Binding of the Retinoblastoma Protein

1993-10-01

Abstract excerpt

Loss of a functional retinoblastoma tumor suppressor gene product, pRB, is a key step in the development of many human tumors. pRB is a negative regulator of cell proliferation and appears to participate in control of entry into the S phase of the cell cycle. The recent demonstration that pRB binds to transcription factor E2F has provided a model for the mechanism of pRB-mediated growth regulation. Since adenoviru...

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Identifiers and source

Literature Corpus work: a6107060-4846-5f3a-9c50-c586fdc85da4
DOI: 10.1128/mcb.13.10.6501-6508.1993

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