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Article

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

Genes & development - 1 Feb 1992

Hiebert S W, Chellappan S P, Horowitz J M, Nevins J R

Abstract excerpt

Recent experiments have shown that the E2F transcription factor is in a complex with the RB1 gene product. The E2F-pRB complex can be reconstituted in an in vitro assay using a GST-RB fusion protein isolated from Escherichia coli. This interaction is dependent on pRB sequences involved in E1A/T-antigen binding as well as carboxy-terminal pRB sequences that are not necessary for E1A/T binding. Moreover,...

Topics

Adenovirus Early Proteins
Antigens, Viral, Tumor
Carrier Proteins
Cell Cycle Proteins
Chloramphenicol O-Acetyltransferase
DNA-Binding Proteins
E2F Transcription Factors
Genes, Retinoblastoma
HeLa Cells
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oncogene Proteins, Viral

Precipitin Tests

Promoter Regions, Genetic

Recombinant Fusion Proteins

Retinoblastoma Protein

Retinoblastoma-Binding Protein 1

Transcription Factor DP1

Source

Identifiers

PMID: 1531329
DOI: 10.1101/gad.6.2.177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1531329-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.PMID 1531329Read ↗

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