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Article

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

Genes & development - 1 Feb 1992

Hiebert S W, Chellappan S P, Horowitz J M, Nevins J R

Abstract excerpt

Recent experiments have shown that the E2F transcription factor is in a complex with the RB1 gene product. The E2F-pRB complex can be reconstituted in an in vitro assay using a GST-RB fusion protein isolated from Escherichia coli. This interaction is dependent on pRB sequences involved in E1A/T-antigen binding as well as carboxy-terminal pRB sequences that are not necessary for E1A/T binding. Moreover,...

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Identifiers

PMID: 1531329
DOI: 10.1101/gad.6.2.177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.PMID 1531329Read ↗

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