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Article

Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product.

The EMBO journal - 1 Nov 1996

Zacksenhaus E, Jiang Z, Phillips R A, Gallie B L

Abstract excerpt

The retinoblastoma gene product, pRb, negatively regulates cell proliferation by modulating the activity of the transcription factor E2F1 that controls expression of S-phase genes. To dissect transcriptional regulation of E2F1 by pRb, we developed a means to control the subcellular localization of pRb by exchanging its constitutive nuclear localization signal (NLS) with an inducible nuclear targeting domain from...

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PMID: 8918469
PMCID: PMC452360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product.PMID 8918469Read ↗

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

Twists in views on RB functions in cellular signaling, metabolism and stem cells.Semantic proximity Read ↗

Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation.Semantic proximity Read ↗

pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.Semantic proximity Read ↗

Conserved RB functions in development and tumor suppressionSemantic proximity Read ↗

Activity of the Retinoblastoma Family Proteins, pRB, p107, and p130, during Cellular Proliferation and DifferentiationSemantic proximity Read ↗

Inhibition of E2F-1 Transactivation by Direct Binding of the Retinoblastoma ProteinSemantic proximity Read ↗

Visualizing dynamic E2F-mediated repression in vivo.Semantic proximity Read ↗

A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.Semantic proximity Read ↗

Alterations in G1/S cell-cycle control contributing to carcinogenesis.Semantic proximity Read ↗

Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins.Semantic proximity Read ↗

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family membersSemantic proximity Read ↗

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