Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product.

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Article

Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product.

The EMBO journal - 1 Nov 1996

Zacksenhaus E, Jiang Z, Phillips R A, Gallie B L

Abstract excerpt

The retinoblastoma gene product, pRb, negatively regulates cell proliferation by modulating the activity of the transcription factor E2F1 that controls expression of S-phase genes. To dissect transcriptional regulation of E2F1 by pRb, we developed a means to control the subcellular localization o...

Topics

3T3 Cells
Alleles
Animals
Base Sequence
Binding Sites
Carrier Proteins
Cell Cycle Proteins
Cell Line
Cell Nucleus
Cytoplasm
DNA Primers
DNA-Binding Proteins
E2F Transcription Factors
E2F1 Transcription Factor
Genes, Retinoblastoma
Mice
Promoter Regions, Genetic
Receptors, Glucocorticoid

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Identifiers

PMID: 8918469
PMCID: PMC452360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8918469-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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