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Novel Mechanisms of E2F Induction by BK Virus Large-T Antigen: Requirement of Both the pRb-Binding and the J Domains

1 Mar 1998

Abstract excerpt

E2F activity is regulated in part by the retinoblastoma family of tumor suppressor proteins. Viral oncoproteins, such as simian virus 40 (SV40) large-T antigen (TAg), adenovirus E1A, and human papillomavirus E7, can disrupt the regulation of cellular proliferation by binding to pRb family members and dissociating E2F-pRb family protein complexes. BK virus (BKV), which infects a large percentage of the human...

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PMID: 9488491
DOI: 10.1128/mcb.18.3.1746

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Novel Mechanisms of E2F Induction by BK Virus Large-T Antigen: Requirement of Both the pRb-Binding and the J DomainsPMID 9488491Read ↗

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The J Domain of Simian Virus 40 Large T Antigen Is Required To Functionally Inactivate RB Family ProteinsSemantic proximity Read ↗

Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors.Semantic proximity Read ↗

Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.Semantic proximity Read ↗

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.Semantic proximity Read ↗

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Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation.Semantic proximity Read ↗

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