Article
Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein.
Molecular and cellular biology - 1 Jun 1996
Dimri G P, Nakanishi M, Desprez P Y, Smith J R, Campisi J
Abstract excerpt
p21Sdi1/WAF1/Cip1 inhibits cyclin-dependent protein kinases and cell proliferation. p21 is presumed to inhibit growth by preventing the phosphorylation of growth-regulatory proteins, including the retinoblastoma tumor suppressor protein (pRb). The ultimate effector(s) of p21 growth inhibition, however, is largely a matter of conjecture. We show that p21 inhibits the activity of E2F, an essential...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.