Article
Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein.
Molecular and cellular biology - 1 Jun 1996
Dimri G P, Nakanishi M, Desprez P Y, Smith J R, Campisi J
Abstract excerpt
p21Sdi1/WAF1/Cip1 inhibits cyclin-dependent protein kinases and cell proliferation. p21 is presumed to inhibit growth by preventing the phosphorylation of growth-regulatory proteins, including the retinoblastoma tumor suppressor protein (pRb). The ultimate effector(s) of p21 growth inhibition, ho...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Binding Sites
- Carrier Proteins
- Cell Cycle Proteins
- Cell Division
- Cell Line
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases
- Cyclins
- DNA
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor