Article

The systemic JIA synovial fluid environment supports development and prevalence of specific inflammatory T helper cell phenotypes

2025-07-04

Abstract excerpt

<h4>Objective</h4> The potential involvement of adaptive immunity in systemic juvenile idiopathic arthritis (sJIA) pathophysiology remains an intriguing question. Here, we investigated whether and how the inflammatory environment in sJIA versus JIA synovial fluid (SF) may differentially impact T helper (Th) cell polarization and activation. <h4>Methods</h4> SF samples from sJIA and JIA patients (both n=7) were t...

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Literature Corpus work: a600b3e3-52a2-53d8-bc63-e332d06fb05f
DOI: 10.1101/2025.07.01.661738

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