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Article

T Cell Dysregulation in Rheumatoid Arthritis: from Genetic Susceptibility to Established Disease.

Current rheumatology reports - 25 Jan 2025

Chin Athena, Small Annabelle, Wong Soon Wei, Wechalekar Mihir D

Abstract excerpt

PURPOSE OF REVIEW: Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation of the synovial tissue, where T cells play a central role in pathogenesis. Recent research has identified T peripheral helper (Tph) cells as critical mediators of local B cell activation in inflamed tissues. This review synthesizes the latest advancements in our understanding the of the role of T...

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Identifiers

PMID: 39862300
DOI: 10.1007/s11926-025-01180-1
PMCID: PMC11762599

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