Back to search

Article

Aberrant naive CD4+ T Cell differentiation in systemic juvenile idiopathic arthritis is committed to B cell help

2022-02-02

Abstract excerpt

<h4>Objective</h4> Systemic juvenile idiopathic arthritis (sJIA) features characteristics of autoinflammation and autoimmunity, culminating in chronic arthritis. Previous work indicated decreased IFNγ-expression by T helper (Th) cells in sJIA. Here, we hypothesized this to result from aberrant or incomplete Th cell polarization. <h4>Methods</h4> Cells or sera were obtained from healthy controls (HC, n=26) and sJIA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2f24d318-ff78-55aa-839f-281d6233c84a
DOI
10.1101/2022.02.01.22270100
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Aberrant naive CD4+ T Cell differentiation in systemic juvenile idiopathic arthritis is committed to B cell helpDOI 10.1101/2022.02.01.22270100
The systemic JIA synovial fluid environment supports development and prevalence of specific inflammatory T helper cell phenotypesSemantic proximity
Children with oligoarticular Juvenile Idiopathic Arthritis have skewed synovial monocyte polarization pattern with functional impairment – a distinct inflammatory pattern for oligoarticular juvenile arthritisSemantic proximity
JIA patient T cells differentiate into Th1, Th17 and Th1.17 effector cells under Th1 polarizing conditionsSemantic proximity
Innately Adaptive or Truly Autoimmune: Is There Something Unique About Systemic Juvenile Idiopathic Arthritis?Semantic proximity
Antigen-driven PD-1 <sup>+</sup> <i>TOX</i> <sup>+</sup> <i>EOMES</i> <sup>+</sup> and PD-1 <sup>+</sup> <i>TOX</i> <sup>+</sup> <i>BHLHE40</i> <sup>+</sup> synovial T lymphocytes regulate chronic inflammation <i>in situ</i>Semantic proximity
Immune Cell-Related Genes in Juvenile Idiopathic Arthritis Identified Using Transcriptomic and Single-Cell Sequencing DataSemantic proximity
A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environmentSemantic proximity
A novel innate lymphoid cell delineates childhood autoimmune arthritisSemantic proximity
Monocyte and bone marrow macrophage transcriptional phenotypes in systemic juvenile idiopathic arthritis reveal TRIM8 as a mediator of IFN-γ hyper-responsiveness and risk for macrophage activation syndrome.Semantic proximity
Large-scale Integrative Analysis of Juvenile Idiopathic Arthritis for New Insight into Its PathogenesisSemantic proximity
Transcriptomic signatures of classical monocytes reveal pro-inflammatory modules and heterogeneity in polyarticular juvenile idiopathic arthritis.Semantic proximity
Generation of a T cell receptor, cytokine and cell repertoire synovial fluid atlas to define commonalities and dissimilarities between arthritic diseases through systems immunology approachesSemantic proximity
Select a neighboring publication to make it the new centre.