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Article

Role of resilience in modifying the links between genetic propensity for mental disorders and irritability.

Journal of affective disorders - 15 Nov 2026

Saarinen Aino, Lyytikäinen Leo-Pekka, Lavonius Veikka, Asikainen Timo, Sormunen Elina, Kähönen Mika, Hietala Jarmo, Raitakari Olli, Lehtimäki Terho, Keltikangas-Järvinen Liisa

Abstract excerpt

AIMS: We examined (1) whether polygenic risk scores for schizophrenia (PRSSCZ), major depression (PRSMDD), and posttraumatic stress disorder (PRSPTSD) explain irritability between ages 20 and 50 and (2) whether these associations are modified by early psychosocial resilience. METHODS: Participants came from the prospective, population-based Young Finns Study (n = 1272-2212). The most recent available genome-wide...

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PMID: 42349527
DOI: 10.1016/j.jad.2026.122174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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