Article

Oligodendrocyte maturation alters the cell death mechanisms that cause demyelination

2023-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Myelinating oligodendrocytes die in human disease and early in aging. Despite this, little is known about the mechanisms that govern cell death across the oligodendrocyte lineage. Here we used a combination of intravital imaging, single-cell ablation, and cuprizone intoxication to show that oligodendrocyte maturation dictates the dynamics and mechanisms of death. After single-cell genotoxic dama...

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Literature Corpus work: a5f4fb35-2d0a-5c85-99aa-7a8b67e28d3b
DOI: 10.1101/2023.09.26.557781

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