Article

Local demyelination rekindles oligodendrocyte precursor dynamics and remyelination in old age

2026-02-16

Abstract excerpt

Cortical myelination is critical for circuit function, plasticity, and long-term stability in the adult brain. With age and disease, the capacity to restore myelin after oligodendrocyte (OL) loss declines, and this failure is thought to reflect intrinsic limitations of OL precursor cells (OPCs) and a loss of permissive cues within the cortical environment. Here, using single-OL ablations and intravital imaging in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d4ddd008-53f6-569a-b74d-f28cabd387da
DOI: 10.64898/2026.02.15.705983

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Local demyelination rekindles oligodendrocyte precursor dynamics and remyelination in old ageDOI 10.64898/2026.02.15.705983Read

Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal ActivitySemantic proximity Read

Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespanSemantic proximity Read

Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths that are vulnerable to degeneration with ageSemantic proximity Read

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelinationSemantic proximity Read

BMAL1 loss in oligodendroglial lineage cells dysregulates myelination and sleepSemantic proximity Read

Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelinSemantic proximity Read

Human glial progenitor cells effectively remyelinate the demyelinated adult brainSemantic proximity Read

Oligodendrocyte maturation alters the cell death mechanisms that cause demyelinationSemantic proximity Read

Motor Learning Promotes Remyelination via New and Surviving OligodendrocytesSemantic proximity Read

Protocol to isolate a large amount of functional oligodendrocyte precursor cells from the cerebral cortex of adult mice and humans.Semantic proximity Read

The Lateral/Caudal Ganglionic Eminence Makes a Limited Contribution to Cortical OligodendrocytesSemantic proximity Read

Multiple sclerosis iPSC-derived oligodendroglia conserve their intrinsic properties to functionally interact with axons and glia in vivoSemantic proximity Read