Article

PRC2 and MYC repression drives oncofetal reprogramming and autophagy dependence in Colorectal Cancer

2026-03-20

Abstract excerpt

<title>Abstract</title> <p>The emergence of an oncofetal phenotype in colorectal cancer (CRC) has been linked to therapy resistance and metastatic progression. However, whether this state pre-exists in treatment-naïve tumors or is primarily acquired upon chemotherapy, and the molecular mechanisms underlying these transitions, remain incompletely understood. While transcriptional regulators such as YAP1 and AP1 ha...

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Literature Corpus work: a5eb30c8-fbbc-563b-8cdf-ac11b2c6a900
DOI: 10.21203/rs.3.rs-9151067/v1

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