Article
Spike mutation D614G alters SARS-CoV-2 fitness.
Nature - 1 Apr 2021
Plante Jessica A, Liu Yang, Liu Jianying, Xia Hongjie, Johnson Bryan A, Lokugamage Kumari G, Zhang Xianwen, Muruato Antonio E, Zou Jing, Fontes-Garfias Camila R, Mirchandani Divya, Scharton Dionna, Bilello John P, Ku Zhiqiang, An Zhiqiang, Kalveram Birte, Freiberg Alexander N, Menachery Vineet D, Xie Xuping, Plante Kenneth S, Weaver Scott C, Shi Pei-Yong
Abstract excerpt
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein substitution D614G became dominant during the coronavirus disease 2019 (COVID-19) pandemic1,2. However, the effect of this variant on viral spread and vaccine efficacy remains to be defined. Here we engineered the spike D614G substitution in the USA-WA1/2020 SARS-CoV-2 strain, and found that it enhances viral replication in human lung...
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