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Article

Integrative proteogenomic characterization of early esophageal cancer.

Nature communications - 25 Mar 2023

Li Lingling, Jiang Dongxian, Zhang Qiao, Liu Hui, Xu Fujiang, Guo Chunmei, Qin Zhaoyu, Wang Haixing, Feng Jinwen, Liu Yang, Chen Weijie, Zhang Xue, Bai Lin, Tian Sha, Tan Subei, Xu Chen, Song Qi, Liu Yalan, Zhong Yunshi, Chen Tianyin, Zhou Pinghong, Zhao Jian-Yuan, Hou Yingyong, Ding Chen

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis is still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving waves in ESCC progression, and reveals the molecular characterization of alcohol drinking habit associated signatures. We...

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Carcinoma, Squamous Cell
Esophageal Cancer Research and Treatment
Esophageal Neoplasms
Esophageal Squamous Cell Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic and Hepatic Oncology Research

RNA modifications and cancer

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Open in PubMed Open full text

Identifiers

PMID: 36966136
DOI: 10.1038/s41467-023-37440-w
PMCID: PMC10039899

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