Article
An insert in the covS gene distinguishes a pharyngeal and a blood isolate of Streptococcus pyogenes found in the same individual.
Microbiology (Reading, England) - 1 Oct 2010
Garcia Alan F, Abe Lucienne M, Erdem Guliz, Cortez Chari L, Kurahara David, Yamaga Karen
Abstract excerpt
Expression of the extensive arsenal of virulence factors by Streptococcus pyogenes is controlled by many regulators, of which CovRS is one of the best characterized and can influence ∼15 % of the genome. Animal models have established that mutants of covRS arise spontaneously in vivo resulting in highly invasive organisms. We analysed a pharyngeal and a blood isolate of S. pyogenes recovered from the same...
Topics
- Bacterial Proteins
- Base Sequence
- Blood
- Child
- DNA, Bacterial
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Genetic Complementation Test
- Histidine Kinase
- Humans