Article

Iron Chelation Improves Ineffective Erythropoiesis and Iron Overload in Myelodysplastic Syndrome Mice

2022-10-07

Abstract excerpt

<h4>ABSTRACT</h4> Myelodysplastic syndrome (MDS) is a heterogeneous group of bone marrow stem cell disorders characterized by ineffective hematopoiesis and cytopenias, most commonly anemia. Red cell transfusion therapy for anemia in MDS results in iron overload, correlating with reduced overall survival. Whether treatment of iron overload benefits MDS patients remains controversial. We evaluate underlying iron-re...

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Literature Corpus work: a57d565f-77f6-5915-b6ed-7a792e490145
DOI: 10.1101/2022.10.05.510967

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