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Genetic iron overload aggravates, and pharmacological iron restriction improves, MDS pathophysiology in a preclinical study

22 Oct 2024

Abstract excerpt

ABSTRACT: Although iron overload is a common feature in myelodysplastic syndromes (MDS), it remains unclear how iron excess is detrimental for disease pathophysiology. Taking advantage of complementary approaches, we analyzed the impact of iron overload and restriction achieved through genetic activation of ferroportin (FPN) via the C326S mutation (FPNC326S) and pharmacologic inhibition (vamifeport) of the iron...

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PMID: 39437711
DOI: 10.1182/blood.2024026135

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