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Deferasirox, an iron chelator, impacts myeloid differentiation by modulating NF ‐ kB activity via mitochondrial ROS

26 Sept 2024

Abstract excerpt

The iron chelator deferasirox (DFX) is effective in the treatment of iron overload. In certain patients with myelodysplastic syndrome, DFX can also provide a dramatic therapeutic benefit, improving red blood cell production and decreasing transfusion requirements. Nuclear Factor-kappa B (NF-kB) signalling has been implicated as a potential mechanism behind this phenomenon, with studies focusing on the effect of...

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PMID: 39327763
DOI: 10.1111/bjh.19782

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