Article

The Effects of Secondary Iron Overload and Iron Chelation on A Radiation-Induced Acute Myeloid Leukemia Mouse Model

2020-10-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Patients with myelodysplastic syndrome (MDS) require chronic red blood cell (RBC) transfusion due to anemia. Multiple RBC transfusions cause secondary iron overload and subsequent excessive generation of reactive oxygen species (ROS), which leads to mutations, cell death, organ failure, and inferior disease outcomes. We hypothesize that iron loading promotes AML...

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Literature Corpus work: 08b9795d-2cd7-5da3-8caf-44ec136fda58
DOI: 10.21203/rs.3.rs-72210/v1

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