Article

Aurora A kinase activation contributes to the fibrotic phenotype in Systemic Sclerosis through primary cilia shortening

2026-03-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Systemic sclerosis (SSc) is a severe autoimmune disease characterised by progressive fibrosis driven by fibroblast activation. Primary cilia, key hubs for profibrotic signalling, are markedly shortened in SSc fibroblasts, but the mechanisms underlying this phenotype remain unclear. This study aimed to define the signalling pathways responsible for primary cilia shortening an...

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Literature Corpus work: a5793beb-61af-5347-8020-81fa542fe9ea
DOI: 10.64898/2026.03.13.711548

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