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Article

Aurora A kinase activation contributes to the fibrotic phenotype in systemic sclerosis through primary cilia shortening.

Arthritis research & therapy - 7 May 2026

Wells Rebecca, Caballero-Ruiz Begoña, Mulipa Panji, Timmis Alex J, Teves Maria E, Varga John, Del Galdo Francesco, Ross Rebecca L, Riobo-Del Galdo Natalia A

Abstract excerpt

BACKGROUND: Systemic sclerosis (SSc) is a severe autoimmune disease characterised by progressive fibrosis driven by fibroblast activation. Primary cilia, key hubs for profibrotic signalling, are markedly shortened in SSc fibroblasts, but the mechanisms underlying this phenotype remain unclear. This study aimed to define the signalling pathways responsible for primary cilia shortening and fibroblast activation in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42098768
DOI: 10.1186/s13075-026-03826-6
PMCID: PMC13317384

Genes

AURKA
HDAC6
CAV1
ROCK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

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