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Article

Rac inhibition reverses the phenotype of fibrotic fibroblasts.

PloS one - 13 Oct 2009

Xu Shi-wen, Liu Shangxi, Eastwood Mark, Sonnylal Sonali, Denton Christopher P, Abraham David J, Leask Andrew

Abstract excerpt

BACKGROUND: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix and produce alpha-smooth muscle actin (alpha-SMA), type I collagen and CCN2 (connective tissue growth factor, CTGF). The basis for this phenomenon is poorly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 19823586
DOI: 10.1371/journal.pone.0007438
PMCID: PMC2757676

Genes

CCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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