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Article

Morphological reprogramming of primary cilia length mitigates the fibrotic phenotype in fibroblasts across diverse fibrotic conditions.

Journal of cell science - 15 Oct 2025

Verma Priyanka, Yalavarthi Bharat, Bhattacharyya Swati, Khanna Dinesh, Gudjonsson Johann E, Tsoi Lam C, Wells Rebecca, Ross Rebecca L, Riobo-Del Galdo Natalia, Del Galdo Francesco, Fortier Sean M, Teves Maria E, Varga John, Bhattacharyya Dibyendu

Abstract excerpt

Myofibroblast differentiation, which occurs across fibrotic diseases, is marked by actin polymerization and assembly of α-smooth muscle actin (αSMA) stress fibers. Primary cilia (PC) are solitary membrane-bound organelles present on the majority of cells. PC length regulation is a complex process influenced by actin polymerization. We discovered that fibroblasts from diverse fibrotic conditions display...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40958676
DOI: 10.1242/jcs.264191

Genes

PC
ACTA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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