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Article

Imbalance of Ciliary Programs Drives Fibroblast Differentiation and Fibrotic Signaling in Systemic Sclerosis

2026-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Systemic sclerosis (SSc) is a chronic fibrotic disease characterized by accumulation of activated profibrotic myofibroblasts in multiple organs. The mechanisms triggering pathogenic fibroblast to myofibroblast reprogramming in SSc, and maintaining the activated myofibroblast state, are not well known. Recent studies show that primary cilia (PC), solitary sensory organelles that integrate diverse...

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Literature Corpus work
80d84670-68b9-5d4f-92a1-e658e46d9758
DOI
10.64898/2026.02.25.707978
Open publication

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